Immunomodulating compounds
1. IK14800 reduces DNA damage in the skin following exposure to ultraviolet irradiation, re-invigorates exhausted T cells, and suppresses growth of melanoma metastases. Notably, despite use of sunscreens the global incidence of skin cancers continues to rise.
2. IK15800 has potential to enhance vaccine efficacy given synergistic induction of type I IFNs in combination with TLR9 agonists, biostability in human serum and depot retention upon injection. More effective vaccines against selected cancers and viral pathogens, eg, Ebola, remain an unmet need.
3. IK14004
a. Raises the possibility of exploiting mechanisms to enhance anticancer immunity as seen for immune checkpoint inhibitors without compromising immune tolerance.
b. Exhibits potential to reverse the dysfunctional immune responses associated with the pathogenesis of Endometriosis.
Complexity of endometriosis: not just a pelvic disorder
The immunomodulating effect of peptide IK14004 on endometriosis and neural sensitisation is the subject of intense investigation by InterK Peptide Therapeutics Ltd.
A link to a recent article in the Australian and New Zealand Journal of Obstetrics and Gynaecology follows:
An Immunomodulating Peptide With Potential to Counteract Endometriosis
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